El tratamiento de lasDepartment Chirurgie Klinik f Skin diseases on the nose are seen in a variety of medical disciplines. Dermatologists, otorhinolaryngologists, general practitioners and general plastic. The term Marjolin's ulcer means the malignant transformation of chronic ulcers, sinus tract and burn scars. The most frequently produced neoplasm is squamous cell. Il carcinoma squamo-cellulare di Marjolin o ulcera di Marjolin Several recent studies have identified nuclear factor-. Besides this transcription factor, essential in. Marjolin's ulcer is a rare, aggressive condition that arises on chronic skin lesions and diseases. Inthis article, we will report 83 cases of this disease. Forschungsdatenbank Freiburg. Als Narbenkarzinom, auch Marjolin-Ulcus genannt, bezeichnet man einen aus chronischen Irritationen heraus entstehenden b. Cutaneous lesions of the nose. Abstract. Skin diseases on the nose are seen in a variety of medical disciplines. Dermatologists, otorhinolaryngologists, general practitioners and general plastic and dermatologic surgeons are regularly consulted regarding cutaneous lesions on the nose. This article is the second part of a review series dealing with cutaneous lesions on the head and face, which are frequently seen in daily practice by a dermatologic surgeon. In this review, we focus on those skin diseases on the nose where surgery or laser therapy is considered a possible treatment option or that can be surgically evaluated. Review. Anatomical characteristics. The nose is the central part of the mid- face and has an important functional, aesthetic and psychological role. Nasal respiration, olfaction and phonation are among its most important functional roles. In addition, the aesthetic importance and its impact on the individual psyche have been the subjects of many previous studies . For example, when looking at a face, observers spend the largest amount of gaze time on the nose and eyes, underscoring its prominent position in the central face . The exposed localization on the face is also cause for increased exposure to ultraviolet (UV) light, which represents one of the most dangerous strains for the skin in this particular location because it is a proven carcinogen. This accounts for the high incidence of cancerous involvement of the skin of the nose, which has proven to be the most common site for skin cancer on the human body . Furthermore, this has lead to the description of the face as a . Consequently, UV light exposure is increased, which also includes exposure to the dangerous UV- B spectrum (2. Typical UV- B- induced DNA damage involves the generation of dimeric photoproducts between adjacent pyrimidine bases. The tumor suppressor gene p. UV- R- induced mutations. Moreover, UV- A generates highly reactive free radicals, damaging DNA and promoting skin cancer. In addition to its role as a potent carcinogen, UV- A is responsible for damage to the collagen structure, leading to accelerated skin aging . The skin in the areas of the dorsum, columella and sidewalls is thin, loose, compliant and relatively less sebaceous . The skin in the areas of the nasal tip and alae is thicker, more sebaceous, more adherent and less flexible . Surgical procedures on the skin of the nose have to respect these different qualities and the nasal topography, including the nasal aesthetic subunits, to achieve the best possible result. The different aesthetic subunits are the tip subunit, columella subunit, dorsal subunit, right and left alar base subunits, right and left alar side wall subunits and right and left dorsal side wall subunits . The anatomical nasal subunits include the dorsum, sidewalls, lobule, soft triangles, alae and columella. The concept of subunits of the external tissue of the nose has proven useful for planning reconstruction. If more than 5. 0% of the subunit is lost it is favorable to replace the whole subunit with regional tissue or a transplant from a donor site . The most important skin diseases on the nose that can require surgical consultation or successfully undergo laser therapy are described below. The description of all dermatoses that can involve the nose would extend beyond the scope of this review. Therefore, our description is limited to those calling for laser or surgical therapy and to those that are clinically most important in the daily practice of a dermatologic surgeon. Non- malignant tumors of the nose. A variety of benign skin tumors of the nose are part of daily practice in dermatologic surgery. Such conditions present with different peculiarities and causes. Causes for development of non- malignant tumors of the nose range from simple histomorphologic characteristics, such as the high concentration of sebaceous glands and increased UV- light exposure to more complex genetic abnormalities such as mutations, which can lead to the conditions described briefly below. Comedo. Comedos are dilated sebaceous ducts consisting of hyper- proliferating ductal keratinocytes and sebum. They can be either open or closed. The nose with its sebaceous skin at the nasal tip and alae can frequently exhibit comedos . Interleukin 1- alpha, which is present in 7. Furthermore, pilosebaceous ducts have androgen receptors, and estradiol treatment reduces comedos. Therefore, it has been proposed that androgens play a significant role in comedo formation . A comedo reaction to different forms of irradiation (megavoltage, cobalt) has been described in the literature . Changes in lipid composition of the sebum that lead to duct hyper- proliferation have been hypothesized as causative for this radio- oncologic phenomenon . In addition to desquamation therapy with topical salicylic or retinoic acid, manual extraction by a cosmetician and physical removal by electrocautery or CO2 laser therapy have also been reported . Multiple closed comedos at the nasolabial fold and the alar of the nose. Fibrous papule of the nose (syn.: benign solitary fibrous papule, fibrous papule of the face)Fibrous papule is a benign condition that commonly appears on the nose (Fig. The size of the firm papule is between 1- 5 mm, and its anatomic distribution predominates at the ala, alar groove and tip of the nose. It has been considered a variant of angiofibroma with a relationship to plasma pro- enzyme factor XIIIa- positive dermal dendrocytes, a population of mononuclear dendritic cells normally present in the papillary and upper reticular dermis . Histopathologically, a clear cell fibrous, hypercellular fibrous, inflammatory fibrous, pigmented fibrous, pleiomorphic fibrous papule and epithelioid variant can be distinguished . A biopsy can be necessary to differentiate fibrous papules from benign adnexal tumors or basal cell carcinomas (BCCs) that sometimes closely resemble its . Small skin- colored papule with smooth surface. Adenoma sebaceum (syn.: Pringle disease)Adenoma sebaceum is an archaic misnomer for angiofibromas on the face without any relationship to sebaceous glands. Adenoma sebaceum is part of the classical triad of tuberous sclerosis (adenoma sebaceum, mental retardation and epilepsy), which is an autosomal dominant neurocutaneous disease resulting from the mutation of TSC- 1 or TSC- 2 . The lesions start to occur in childhood (5- 1. Fig. Different therapy modalities such as electrocoagulation, cryosurgery, shave excision and dermabrasion have all been described. CO2 laser ablation has been shown to be an effective treatment option, with long- lasting improvement and good cosmetic results . Multiple wart- like, waxy lumps consisting of angiomatous and fibrous tissue associated with tuberous sclerosis. Hydrocystoma (syn.: cysts of Moll, sudoriferous cysts)Hydrocystomas are benign cysts of sweat ducts that arise in the apocrine or eccrine glands (Fig. They usually present as solitary translucent bluish nodules. The blue color is due to the Tyndall effect, caused by scattered light. Histopathology shows uni- or multilocular cystic spaces within the dermis. Multiple hydrocystomas have been described in Schopf- Schulz- Passarge syndrome, a rare autosomal recessive genodermatosis characterized by palmoplantar keratodermas, eyelid apocrine hydrocystomas, hypodontia, hypotrichosis and onychodystrophy . The treatment of hydrocystomas with topical trichloracetic acid, simple excision, electrosurgery, CO2 laser or a 1. Multiple small papules. Some are skin- colored; the larger papules are dark (. Men are more frequently affected than woman. Immunosuppressive therapy (e. It is almost always located on the face, including the nose, forehead and lateral cheek parts. Clinically, it appears as a whitish- yellow or skin- colored papule that varies in size (2- 6 mm) with often accompanying seborrhoea oleosa and telangiectasias. A central umbilication (from which a small globule of sebum is sometimes expressed) is the most important clinically diagnostic feature for differentiating between BCC and sebaceous hyperplasia . Although it is a completely benign lesion and does not require treatment, it can sometimes be cosmetically disturbing or clinically resemble BCC; therefore, a biopsy might be necessary in some cases. Therapy consists of photodynamic therapy, topical trichloroacetic acid, laser treatment (pulsed- dye or CO2 laser), electrosurgery, shave excision, excision or oral isotretinoin therapy for multiple widespread disfiguring sebaceous hyperplasia . They protrude from the skin surface and may be pigmented or skin- colored. Upon histological examination, they exhibit nevus cell nests in the dermis. Women are more frequently affected than man (9: 1), and the nevi are mostly located on the face . Estrogens might influence the pathogenesis of these distinctive melanocytic nevi . Because the major challenge is to exclude malignancy, histology should not be disregarded in cases of clinical doubt regarding the diagnosis. Therapy consists of excision, shave excision or CO2 and erbium: YAG or ruby lasers in cases of a firm clinical diagnosis by an experienced dermatologist. Rhinophyma. Rhinophyma is a slow- growing and possibly disfiguring tumor of the nose that primarily affects men in their fifth to seventh decade . It is characterized by the progressive enlargement of the nose caused by sebaceous hyperplasia, follicular plugging, fibrosis and telangiectasia . Although it is currently classified as stage IV rosacea, some authors believe it represents a different disease process . In the past, rhinophyma has often been associated with heavy alcohol consumption, but new studies have shown that there is no significant correlation . The absence of rosacea skin lesions at adjacent skin areas may be the sign of a tumor mimicking rhinophyma. Although rare, sebaceous carcinomas and angiosarcomas, as well as the more common BCCs and SCCs, are sometimes concomitantly present .
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Curious Contributions To Quantum Theory : 1. Cosmos And Culture : NPRDear 1. I'm very happy to introduce you to Prof. David Kaiser, who is the head of the Program in Science, Technology, And Society (STS) at MIT. He is an accomplished historian of modern physics and is a research cosmologist. Dave has a new book coming out exploring the unlikely roots of the . I highly recommend it! The book had first been published in 1. I found it, it had long since become an international bestseller. Title: How The Hippies Saved Physics Author: Heike Freud Subject: how the hippies saved physics Keywords: Read Online how the hippies saved physics, how the hippies saved physics PDF, Download how the hippies saved physics. 0.0MB By Jack Sarfatti 1. Scitation Author Page. View Affiliations Hide Affiliations. Notes on the hippies who saved physics. Today 66, 2, 9 (Fri Feb 01 00:00:00. Title: How The Hippies Saved Physics Subject: How The Hippies Saved Physics Keywords: Download or Read Online how the hippies saved physics PDF Created Date: 9/9/2016 2:48:48 PM. I remember being captivated by the book's discussion of modern physics: the strangenesses of relativity and quantum theory, the subtle dance of subatomic particles. Capra's earnest discussions of Eastern spirituality left far less of an impression on me. But his great joy and excitement about the deep mysteries of modern physics were hard to miss. I went to college determined to study physics, inspired by some marvelous high school teachers and also by books like Capra's. There I became fascinated by Bell's theorem and quantum entanglement: an elegant demonstration, first published by physicist John Bell in 1. Tickle a particle here, and its partner should instantly dance, no matter how far away it had traveled. Today, Bell's theorem is at the heart of everything from quantum computing and quantum teleportation to quantum encryption and more. Yet the beguiling, instantaneous connections sit rather uneasily with Einstein's relativity, which stipulates that nothing can travel faster than light. While pursuing my Ph. D. Only later did I learn that the experiment had first been conducted in Berkeley, California, in the early 1. John Clauser, who had been one of the charter members of a spirited, informal discussion group known as the . After several years of research, the product of that digging has just been published: How the Hippies Saved Physics: Science, Counterculture, and the Quantum Revival (W. 37 Responses to How the Hippies Saved Physics. Dave Miller says: June 13, 2011 at 7:30 pm. Title: How The Hippies Saved Physics Author: Angelika Bayer Subject: how the hippies saved physics Keywords. Title: How The Hippies Saved Physics Subject: How The Hippies Saved Physics Keywords: Download or Read Online how the hippies saved physics PDF Created Date: 9/11/2016 5:09:23 AM. Get Instant Access to free Read PDF How The Hippies Saved Physics at Our Ebooks Unlimited Database 1/4 How The Hippies Saved Physics How The Hippies Saved Physics PDF Download How The Hippies Saved Physics.PDF How The Hippies. Norton, 2. 01. 1). The young physicists who founded the Fundamental Fysiks Group in the 1. Title: How The Hippies Saved Physics Subject: How The Hippies Saved Physics Keywords: Download or Read Online how the hippies saved physics PDF Created Date: 9/19/2016 3:47:52 AM.Despite holding Ph. D. s from some of the nation's most prestigious physics departments, they entered the field just as the job market for physicists crashed . But once they arrived, they found themselves sitting smack- dab in the middle of a burgeoning counterculture. Mainstream newspapers reported on everything from mind- reading experiments to tests of extra- sensory perception and other, equally bizarre- sounding, phenomena. Several members of the Fundamental Fysiks Group began to wonder whether Bell's theorem . Perhaps it could even open up a new understanding of human consciousness. Some members of the group sought cash from unlikely sources to pursue their quest, ranging from the Central Intelligence Agency to self- made entrepreneurs in the California . And they set up shop in that hotbed of New Age enthusiasm, the Esalen Institute in beautiful Big Sur, California. They circulated preprints in an extensive, underground network, and broke into the popular- book market with bestsellers like Capra's Tao of Physics and Gary Zukav's Dancing Wu Li Masters. Along the way, they produced some fascinating work that, stripped of its original packaging, has entered the mainstream today. Some highlights include: — Fundamental Fysiks Group members dominated worldwide publications on Bell's theorem and quantum entanglement, recognizing their groundbreaking importance years before most physicists began to pay attention to the topic.— Every single demonstration that quantum entanglement could be compatible with Einstein's relativity came either directly from members of the Fundamental Fysiks Group or as direct responses to their calculations and thought experiments.— In the process of refuting a particularly clever thought experiment by group member Nick Herbert, three separate groups of physicists . The no- cloning theorem stipulates that it is impossible to make exact copies or clones of an unknown quantum state. In short order, the no- cloning theorem became the linchpin of the first protocol for quantum encryption.— Herbert's thought experiment likewise instigated the first- ever demonstrations of a fundamental quantum limit on amplifiers like lasers: their behavior at the single- quantum level departs significantly from their ordinary operation, as only became clear in the process of tackling Herbert's intriguing challenge.— Books and articles by group members provided some of the earliest resources for teaching Bell's theorem . As I discuss in the book's introduction, the title is meant to be partly tongue- in- cheek. I don't believe that any small group of scientists could possibly . Moreover, as I detail in the book, members of the Fundamental Fysiks Group interacted with several other physicists around the world, including great leaders like John Wheeler, Richard Feynman, and Eugene Wigner. Those interactions sparked some beautiful and lasting insights into the deepest questions of space, time, and matter. The playful title is meant to signal that some serious work was going on amid the antics of the time, and to highlight the remarkable gap between group members' intellectual ambitions and the humbleness of their professional platform. Even more interesting for me is the question of how a wider context can shape scientific work. It mattered a great deal that most members of the Fundamental Fysiks Group had been well- trained in leading universities. It also mattered that they were pursuing their work outside the usual institutions, sitting amid the blossoming New Age and counterculture movements of the 1. San Francisco Bay area. That combination of out- of- left- field curiosity with carefully disciplined skills proved potent. Not a bad legacy for a bunch of bright, fun- loving, and underemployed young hippies. Battlefield 1. 94. Galactic Conquest v. 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